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Updated: Oct 6, 2025

Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition
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Anodal Transcranial Direct Current Stimulation (tDCS) Over the Primary Motor Cortex (M1) Enhances Motor Response

Shahid Bashir1, Azzam Bamugaddam2, Muath Alasheikh3

  • 1Neuroscience Center, King Fahad Specialist Hospital Dammam, Dammam, Saudi Arabia.

Medical Science Monitor Basic Research
|January 17, 2022
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Summary

Anodal transcranial direct current stimulation (tDCS) over the primary motor cortex significantly improved inhibitory control and visual recognition memory in healthy adults. This non-invasive brain stimulation shows promise for enhancing cognitive functions.

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Neuromodulation

Background:

  • Transcranial direct current stimulation (tDCS) is a non-invasive brain modulation technique.
  • Anodal tDCS effects on cognition are inconsistent due to variations in parameters and sham conditions.
  • Investigating single-session anodal tDCS over the primary motor cortex (M1) is crucial for understanding its cognitive impact.

Purpose of the Study:

  • To assess the effect of a single session of anodal-tDCS over M1 on response inhibitory control and visual recognition memory in healthy adults.
  • To compare the cognitive outcomes of real tDCS versus sham stimulation.
  • To explore the potential of M1 stimulation for cognitive enhancement.

Main Methods:

  • A randomized, double-blind, sham-controlled study involving 30 healthy male subjects.
  • Application of 2 mA anodal-tDCS for 20 minutes over the primary motor cortex (M1).
  • Cognitive functions assessed using the stop signal task (SST) for inhibitory control and the pattern recognition memory (PRM) task.

Main Results:

  • Statistically significant improvements were observed in the stop signal task (SST) go trial accuracy (P=0.019) and correct response time (P=0.04) after real anodal-tDCS.
  • No significant cognitive effects were found in the sham stimulation group.
  • These results indicate a specific effect of real tDCS on inhibitory control.

Conclusions:

  • Single-session anodal-tDCS applied over M1 enhances inhibitory control and visual recognition memory compared to sham.
  • M1 plays a key role in inhibitory motor control, making it a viable target for tDCS.
  • Anodal-tDCS over M1 may serve as a promising adjuvant therapy for modulating motor response inhibition.