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Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
Published on: April 26, 2016
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Spectrometric Results of Process Variations in Dacarbazine
James T Isaacs1, Philip J Almeter1,2, Bradley S Henderson1
1Department of Pharmacy Services, University of Kentucky, Lexington, KY 40536.
Contact in Context
|January 17, 2022
Abstract:
Intra-lot and inter-lot variability in dacarbazine was detected in the Drug Quality Study (DQS) using Fourier transform near-infrared spectrometry (FTNIR). One vial of six vials sampled from Fresenius Kabi Lot 6125612 appeared 7.8 SDs from the center of the rest of the vials on the DQS FTNIR screening assay. Spectra of 54 vials from six lots in the library clustered in two groups (p=0.02), suggesting they represent different material.
