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Updated: Oct 6, 2025

Anti-Nuclear Antibody Screening Using HEp-2 Cells
Published on: June 23, 2014
Type 2 leprosy reaction presenting as a monoarthritis post multidrug therapy
Isabela Maria Bernardes Goulart1,2,3, Marcela Araujo de Oliveira Santana3, Willian Vargas Tenório da Costa1
1School of Medicine, Federal University of Uberlândia (UFU), 1720, Pará avenue, Uberlândia, MG, Brazil.
Abstract:
Type 2 leprosy reaction, or erythema nodosum leprosum (ENL), involves a complex interaction between the host's immune system and Mycobacterium leprae. It may occur before, during, or after treatment and have a variable clinical presentation involving different body systems, such as skin, osteoarticular, kidneys, and others. Thus, the differential diagnosis, depending on its clinical presentation, can be broad and challenging. The authors report a case of a severe monoarthritis during a type 2 reaction after the multidrug therapy (MDT) was discharged and the investigation of the differential diagnoses.
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