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Serum Creatinine Reference Limits in Pediatric Population-A Single Center Electronic Health Record-Based Database in

Gwo-Tsann Chuang1, I-Jung Tsai1, Yong-Kwei Tsau1

  • 1Department of Pediatrics, National Taiwan University Children's Hospital, Taipei, Taiwan.

Frontiers in Pediatrics
|January 17, 2022
PubMed

Insights

This study establishes age- and sex-specific serum creatinine reference limits for children in Taiwan. These findings aid pediatricians in evaluating kidney function, particularly when baseline data is unavailable.

Area of Science:

  • Pediatric Nephrology
  • Clinical Biochemistry

Background:

  • Serum creatinine is a key indicator of kidney function.
  • Establishing accurate reference ranges is crucial for pediatric renal health assessment.

Purpose of the Study:

  • To determine age- and sex-specific serum creatinine reference limits in a pediatric population in Taiwan.
  • To provide clinical guidance for renal function evaluation in children.

Main Methods:

  • Utilized data from the National Taiwan University Hospital-integrated Medical Database (NTUH-iMD).
  • Excluded individuals with multiple serum creatinine measurements and outliers.
  • Analyzed 27,911 single serum creatinine measurements from children aged 1 month to 18 years.
  • Established 95% reference limits for each age and sex group.

Main Results:

  • Generated comprehensive serum creatinine reference limits for pediatric age and sex groups.
  • Observed that upper reference limits increase with age, reflecting normal physiological changes.
  • Upper reference limits are clinically valuable for interpreting pediatric serum creatinine levels.

Conclusions:

  • Successfully established pediatric serum creatinine reference limits using a Taiwanese hospital database.
  • These reference limits will assist clinicians in assessing pediatric renal function.
  • Provides essential data for evaluating children, especially those lacking prior creatinine measurements.

Keywords:
acute kidney injuryadolescentspediatricsrenal functionserum creatinine

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