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Flow Cytometry

Flow Cytometry

The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
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Updated: Oct 6, 2025

Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 2. General Practices

Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 2. General Practices

Published on: October 3, 2016

Establishing a biosafety plan for a flow cytometry shared resource laboratory.

Jessica B Back¹, Lola Martinez², Lauren Nettenstrom³

¹Microscopy, Imaging, and Cytometry Resources Core, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA.

Cytometry. Part a : the Journal of the International Society for Analytical Cytology

|January 17, 2022

Summary

Developing a dynamic biosafety plan is crucial for shared resource laboratories (SRLs) handling diverse biological samples. This plan outlines risk mitigation and educates personnel on safe practices for instrumentation use.

Keywords:

SRL operations biosafety biosafety plan shared resource laboratory

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Last Updated: Oct 6, 2025

Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 2. General Practices

Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 2. General Practices

Published on: October 3, 2016

Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 3. Aerobiology

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Published on: October 3, 2016

Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 1. Biosafety Level 4 Suit Laboratory Suite Entry and Exit Procedures

Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 1. Biosafety Level 4 Suit Laboratory Suite Entry and Exit Procedures

Published on: October 3, 2016

Area of Science:

Laboratory Safety
Microbiology
Biotechnology

Background:

Shared Resource Laboratories (SRLs) require robust biosafety protocols due to the diverse range of biological samples and pathogens encountered.
Establishing comprehensive biosafety practices is essential for protecting personnel and preventing laboratory-acquired infections.
The dynamic nature of pathogens necessitates adaptable biosafety plans within SRLs.

Purpose of the Study:

To provide a foundational structure for creating and maintaining effective biosafety plans in SRLs.
To guide SRL personnel in developing adaptable procedures for handling diverse biological samples and instrumentation.
To enhance biosafety awareness and education among laboratory personnel and users.

Main Methods:

Reviewing institutional resources and collaborating with health and safety personnel.
Developing a flexible framework for biosafety plan implementation.
Outlining essential information regarding biological sample use, risk assessment, and mitigation strategies.

Main Results:

A structured approach to biosafety plan development has been proposed.
Guidance is provided for creating a dynamic, living biosafety plan.
Emphasis is placed on collaboration with institutional health and safety experts.

Conclusions:

An adaptable biosafety plan is vital for SRLs managing diverse biological agents.
Collaboration and utilization of institutional resources are key to effective biosafety plan generation.
The proposed structure aids in establishing and maintaining robust biosafety procedures.