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Atomically Precise Water-Soluble Graphene Quantum Dot for Cancer Sonodynamic Therapy
Yang-Yang Ju1, Xiao-Xiao Shi2, Shu-Yu Xu2
1State Key Laboratory for Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|January 17, 2022
Summary
Atomically precise graphene quantum dots (GQDs) offer deep-red emission and enhanced sonodynamic therapy. This water-soluble GQD exhibits superior anti-cancer properties and good biosafety for tumor treatment.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Graphene quantum dots (GQDs) possess promising bio-applications due to unique optical and chemical properties.
- Heterogeneity in GQD composition, size, and shape hinders structure-property understanding and scalable applications.
- Addressing GQD variability is crucial for advancing manufacturing and safety in biomedical uses.
Purpose of the Study:
- To synthesize and characterize a water-soluble, atomically precise GQD (WAGQD-C96) for biomedical applications.
- To evaluate WAGQD-C96's optical properties, sonodynamic sensitization, and anti-cancer efficacy.
- To assess the biosafety and in vivo performance of WAGQD-C96 for tumor treatment.
Main Methods:
- Synthesis of water-soluble atomically precise GQD (WAGQD-C96) using sterically hindered functional groups for monodispersity.
- Characterization of WAGQD-C96's deep-red emission and sonodynamic sensitization capabilities.
- In vitro and in vivo evaluation of WAGQD-C96's cell uptake, tumor retention, reactive oxygen species generation, tumor inhibition, and biosafety.
Main Results:
- WAGQD-C96 was successfully synthesized, exhibiting deep-red emission and excellent sonodynamic sensitization.
- Monodispersed WAGQD-C96 demonstrated good cell uptake and long-term retention in tumor tissue.
- WAGQD-C96 showed superior reactive oxygen species generation, potent tumor inhibition, and validated biosafety in vivo.
Conclusions:
- Atomically precise WAGQD-C96 offers a promising solution to GQD heterogeneity for biomedical applications.
- WAGQD-C96 functions as an effective anti-cancer sonosensitizer with enhanced efficacy and safety.
- This precise GQD platform facilitates improved understanding and application of GQDs in nanomedicine.
