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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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Hyperlipidemia and hypothyroidism.

Xin Su1, Hua Peng2, Xiang Chen1

  • 1Department of Cardiology, the Xiamen Cardiovascular Hospital of Xiamen University, Xiamen, Fujian, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|January 17, 2022
PubMed
Summary
This summary is machine-generated.

Hypothyroidism elevates cholesterol and triglycerides by altering thyroid hormone levels. This review explores how hypothyroidism impacts hyperlipidemia and cardio-metabolic disease risk.

Keywords:
Angiopoietin-like proteinFibroblast growth factorHyperlipidemiaHypothyroidismPCSK9

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Area of Science:

  • Endocrinology
  • Metabolic Research
  • Cardiovascular Science

Background:

  • Hypothyroidism is linked to elevated serum total cholesterol, LDL-C, and triglycerides.
  • Thyroid hormones (THs) are crucial for cholesterol metabolism, influencing production, transformation, and clearance.
  • Thyroid-stimulating hormone (TSH) may also contribute to hyperlipidemia, though mechanisms are under investigation.

Purpose of the Study:

  • To review the relationship between hypothyroidism and hyperlipidemia.
  • To explore the mechanisms by which hypothyroidism promotes hyperlipidemia.
  • To examine hypothyroidism's contribution to cardio-metabolic disease.

Main Methods:

  • Literature review of existing studies on hypothyroidism and lipid metabolism.
  • Analysis of the role of thyroid hormones and TSH in hyperlipidemia.
  • Investigation of novel biomarkers (PCSK9, ANGPTLs, FGFs) in hypothyroidism-induced hyperlipidemia.

Main Results:

  • Hypothyroidism is associated with dyslipidemia, including increased cholesterol and triglycerides.
  • Down-regulated THs and up-regulated TSH are observed in hypothyroidism-related hyperlipidemia.
  • Hypothyroidism can lead to dysfunctional HDL particles and involves biomarkers like PCSK9, ANGPTLs, and FGFs.

Conclusions:

  • Hypothyroidism significantly contributes to the development of hyperlipidemia.
  • Understanding these mechanisms is vital for managing cardio-metabolic risks associated with hypothyroidism.
  • Further research into biomarkers may offer new therapeutic targets.