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Body Composition of Preterm Infants following Rapid Transition to Enteral Feeding
Cornelia Wiechers1, Vanessa Avellina1, Beate Luger1
1Department of Neonatology, University Children's Hospital, Eberhard Karls University, Tübingen, Germany.
Insights
Body composition in very preterm infants fed rapidly was similar to other preterm groups. Fat-free mass was lower in infants small for gestational age, indicating potential growth differences.
Area of Science:
- Neonatology
- Pediatric Nutrition
- Body Composition Analysis
Background:
- Very preterm infants often face challenges with enteral feeding.
- Rapid transition to full enteral feeding is a strategy to improve outcomes.
- Body composition changes in preterm infants require careful monitoring.
Purpose of the Study:
- To evaluate body composition at hospital discharge in very preterm infants.
- To assess the impact of rapid enteral feeding transition on body composition.
- To compare body composition metrics with gestational age and growth parameters.
Main Methods:
- Prospective, observational, cross-sectional study.
- Included 105 preterm infants (<32 weeks gestational age or <1,500g birth weight).
- Measured fat mass/total body mass (BF%) and fat-free mass (FFM) using air displacement plethysmography at discharge.
Main Results:
- At discharge (37.6 weeks postmenstrual age), BF% was 17.0% and FFM was 2,161g.
- BF% was not associated with gestational age at birth.
- Fat-free mass was significantly lower in infants born small for gestational age.
Conclusions:
- Rapid enteral feeding transition resulted in body composition similar to other preterm populations.
- Body composition was associated with postmenstrual age, not gestational age at birth.
- Preterm infants showed lower fat-free mass and higher fat mass compared to term infants, suggesting diminished growth.
Objective:
This study aimed to evaluate body composition at the time of hospital discharge in very preterm infants following rapid transition to full enteral feeding.
Study Design:
We conducted a prospective, observational, cross-sectional study and included 105 preterm infants <32 gestational age or birth weight <1,500 g, born between April 2015 and December 2020, following rapid transition to full enteral feeding (≥140 mL/kg/day). Fat mass/total body mass (BF%) and fat-free mass (FFM) were measured at the time of hospital discharge using air displacement plethysmography.
Results:
Median and interquartile range (Q1-Q3) of gestational age at birth (GA) was 27.3 (26.1-28.7) weeks and birth weight 845 (687-990) g. Time to reach full enteral feeding was 5 (5-7) days. At 37.6 weeks (36.1-39.0) postmenstrual age (PMA), BF% was 17.0% (14.9-19.8) and FFM 2,161 g (1,966-2,432). BF% was not associated with GA, and not different between small and appropriate for gestational age infants. FFM was significantly lower in infants born small for gestational age.
Conclusions:
Following rapid transition to full enteral feeding, FFM and BF% at discharge were similar to other preterm populations. BF% and FFM were not associated with GA at birth but with PMA at measurement. FFM was lower and BF% higher compared to term infants at birth, suggesting diminished parenchymal growth in preterm infants. Continued monitoring of body composition, metabolic health, and neurological development is needed to study long-term effects.
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