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Published on: May 16, 2013
Rosettes: a shield for Plasmodium falciparum against artemisinins?
1Department of Infectious Diseases, Doherty Institute, The University of Melbourne, Melbourne, Victoria, Australia; Department of Medicine (RMH), The University of Melbourne, Melbourne, Victoria, Australia.
Abstract:
Relative resistance of Plasmodium falciparum parasites to artesunate (AS) has been ascribed to mutations in the Kelch 13 gene. Lee et al. describe another potential contributor to resistance: the induction of increased rosetting by trophozoite-infected erythrocytes following short exposures to AS. Dissecting this phenomenon may lead to new insights into AS resistance.
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