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Related Experiment Video

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Heart-on-Chip for Combined Cellular Dynamics Measurements and Computational Modeling Towards Clinical Applications.

Jiyoon Park1, Ziqian Wu1, Paul R Steiner2

  • 1Thayer School of Engineering, Dartmouth College, Hanover, NH, 03755, USA.

Annals of Biomedical Engineering
|January 18, 2022
PubMed
Summary

Organ-on-chip technology offers a novel approach to studying heart conditions and drug toxicity. These microfluidic heart-on-chip devices provide more accurate and efficient drug screening compared to traditional methods.

Keywords:
Cardiovascular disease modelingComputational modelingDrug screeningHeart-on-chipMicrofluidics

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Drug Development

Background:

  • Traditional in vitro and in vivo models for studying cardiovascular pathophysiology and drug-induced cardiotoxicity face limitations including inter-species differences, high costs, and poor predictive accuracy.
  • Organ-on-chip (OOC) or micro-engineered three-dimensional cellular/tissue models are emerging as advanced alternatives.

Purpose of the Study:

  • To review recent advancements and challenges in the development and application of microfluidic heart-on-chip devices.
  • To highlight their potential to revolutionize drug screening and disease modeling in cardiovascular research.

Main Methods:

  • Fabrication and functionalization of microfluidic heart-on-chip platforms.
  • Integration of sensors for real-time electrophysiological and mechanical measurements.
  • Numerical and computational modeling of cardiomyocyte behavior.
  • Review of clinical applications in drug screening and disease modeling.

Main Results:

  • Microfluidic heart-on-chip devices can recapitulate cardiac tissue functionality and cell-extracellular matrix interactions.
  • These platforms enable higher throughput drug screening with real-time extraction of disease-specific phenotypic, genotypic, and electrophysiological information.
  • Electrical and mechanical components can be tailored to mimic in vivo conditions more accurately.

Conclusions:

  • Organ-on-chip technology represents a paradigm shift in cardiovascular research and drug development, offering improved accuracy and efficiency.
  • Current challenges and future perspectives for these platforms in clinical applications are discussed.