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Predicting miscarriage using systemic immune-inflammation index.

Ezgi Turgut1, Muradiye Yildirim1, Bedri Sakcak1

  • 1Department of Obstetrics and Gynecology, Ministry of Health, Ankara City Hospital, Ankara, Turkey.

The Journal of Obstetrics and Gynaecology Research
|January 18, 2022
PubMed
Summary
This summary is machine-generated.

High systemic immune-inflammation index (SII) levels in early pregnancy may predict miscarriage risk in women with threatened abortion. This inflammatory marker could aid in early miscarriage prediction, alongside other clinical factors.

Keywords:
miscarriageneutrophil-to-lymphocyte ratiosystemic immune-inflammation indexthreatened abortion

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Area of Science:

  • Reproductive Medicine
  • Clinical Immunology
  • Obstetrics

Background:

  • Miscarriage, a pregnancy loss before 20 weeks, affects a significant number of pregnancies.
  • Early identification of miscarriage risk is crucial for timely intervention and improved patient outcomes.
  • The systemic immune-inflammation index (SII) reflects the body's inflammatory status and has been explored in various medical conditions.

Purpose of the Study:

  • To investigate the clinical significance of the systemic immune-inflammation index (SII) as a potential predictor of miscarriage.
  • To compare SII values between women experiencing miscarriage and those with viable pregnancies.
  • To assess the utility of SII in patients with a history of threatened abortion.

Main Methods:

  • A retrospective study involving 709 women with miscarriage and 676 women with viable pregnancies (control group).
  • Comparison of demographic characteristics, laboratory results, and SII values between groups.
  • Specific analysis of laboratory results and SII in participants with a history of threatened abortion.

Main Results:

  • The systemic immune-inflammation index (SII) was significantly higher in the miscarriage group compared to the control group (p=0.030).
  • In patients with threatened abortion, elevated leukocyte count, neutrophil count, neutrophil-to-lymphocyte ratio (NLR), and SII were observed in the miscarriage group.
  • Receiver operating characteristic (ROC) curve analysis identified an SII cutoff value of 883.95 (10^9/L) for miscarriage prediction in threatened abortion cases, with 62.6% sensitivity and 62% specificity.

Conclusions:

  • Elevated SII in early pregnancy can serve as an additional predictive marker for miscarriage, particularly in women with threatened abortion.
  • Further development of prediction models incorporating maternal risk factors and multiple markers is recommended for enhanced clinical utility.
  • The findings suggest SII's potential role in risk stratification for early pregnancy complications.