Related Experiment Video
Updated: Oct 6, 2025
Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
Neutralizing SARS-CoV-2 by dimeric side chain-to-side chain cross-linked ACE2 peptide mimetics
Yan-Ni Zhang1, Yuwei Zhang2, Shan Su3
1Department of Health Sciences, Institutes of Physical Science and Information Technology, Anhui University, Hefei 230601, P. R. China. fanggm@ahu.edu.cn.
Abstract:
We present the finding of a dimeric ACE2 peptide mimetic designed through side chain cross-linking and covalent dimerization. It has a binding affinity of 16 nM for the SARS-CoV-2 spike RBD, and effectively inhibits the SARS-CoV-2 pseudovirus in Huh7-hACE2 cells with an IC50 of 190 nM and neutralizes the authentic SARS-CoV-2 in Caco2 cells with an IC50 of 2.4 μM. Our study should provide a new insight for the optimization of peptide-based anti-SARS-CoV-2 inhibitors.
More Related Videos
Related Concept Videos
02:50Conjugated Proteins
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
00:42Cross-reactivity