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Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry
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Cyclic poly(β-amino ester)s with enhanced gene transfection activity synthesized through intra-molecular cyclization
Chenfei Wang1, Xiaobei Huang2, Litao Sun1
1School of Chemical Engineering and Technology, Xi'an Jiaotong University, Xi'an 710049, China. dezhong.zhou@xjtu.edu.cn.
Chemical Communications (Cambridge, England)
|January 18, 2022
Abstract:
Topological structure plays a critical role in gene delivery of cationic polymers. Cyclic poly(β-amino ester)s (CPAEs) are successfully synthesized via sequential Michael addition and free radical initiating ring-closure reaction. The CPAEs exhibit superior gene transfection efficiency and safety profile compared to their linear counterparts.
