Related Experiment Video
Updated: Aug 19, 2026
10:28
An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
Published on: June 7, 2015
Cationic injectable hydrogels for wet-tissue sealing with enhanced red blood cell retention
Chunyu Zhao1, Hanqing Yu1, Jing Lyu1
1Charles Institute of Dermatology, School of Medicine, University College Dublin, Dublin 4, Ireland. rijian.song@ucd.ie.
Chemical Communications (Cambridge, England)
|August 17, 2026
Abstract
None:
A cationic injectable hydrogel was constructed from thiolated hyaluronic acid and acrylate-functionalised hyperbranched poly(ethylene glycol) via thiol-Michael addition, with covalently immobilised quaternary ammonium groups. The resulting network showed rapid gelation within 27-45 s, tuneable wet-tissue sealing, enzyme-responsive wet-mass loss, enhanced red blood cell retention and good cytocompatibility after network formation.
