Quaternized chitin/tannic acid bilayers layer-by-layer deposited poly(lactic acid)/polyurethane nanofibrous mats...

Chronic wounding treatment based on bacterially infected diabetes suffers an essential limitation in persistent skin injuries due to the resistance of progressive antibiotics, which inhibits the process of healing with wound tissue. Therefore, biologically friendly and nontoxic bio-based mats without antibiotics are taken for granted as a versatile platform for biomedical dressing, but urgently necessitates further functional diversification. Herein, a novel tannic acid (TA)/silver (Ag)-modified poly(lactic acid) (PLA)/Polyurethane (PU) antibacterial hybrid nanofibers were successfully constructed by electrospinning technology. Layer-by-layer (LBL) self-assembly technique was utilized to produce membranes via deposited biocompatible quaternized chitin (QC) and TA. The mats are enabled with outstanding flexibility, antibacterial activity, great hemocompatibility, and good ROS-scavenger in a wounding environment. Consequently, the basis of morphology and structure of electrospun membranes was verified by SEM and FT-IR. Besides, the LBL-structured surface was proved to impart improved wettability and hydrophilic via the test of water contact angle. Additionally, antimicrobial experiments demonstrate the effective broad-spectrum antibacterial ability of as-prepared hybrids, inhibiting infection of gram-positive microbial (S. aureus) as well as gram-negative microbial. Finally, the anti-oxidation performance holds great promise in conducive to the formation favorable physiological environment for wound healing. In conclusion, this work establishes a feasible but effective pathway to construct a multifunctional antibacterial dressing for the skin infection.