A dual-signal fluorescent sensor based on MoS₂ and CdTe quantum dots for tetracycline detection in milk

A dual-signal fluorescent sensor was developed for tetracycline (TET) detection in milk with excellent reproducibility and stability. In this protocol, molybdenum disulfide quantum dots (MoS₂ QDs) with blue fluorescence and cadmium telluride quantum dots (CdTe QDs) with yellow fluorescence were synthesized to establish the MoS₂/CdTe-based sensor with two fluorescence emission peaks at 433 nm and 573 nm. With the addition of TET, the fluorescence of MoS₂/CdTe were quenched by photoinduced electron transfer (PET), and the fluorescence of CdTe QDs were quenched more obvious than MoS₂ QDs. With the strategy, a calibration curve was established between the TET concentration in the range of 0.1-1 μM and the ratio of fluorescence intensity at 573 nm and 433 nm (F₅₇₃/F₄₃₃). Furthermore, the dual-signal sensor was applied for TET detection in milk samples with the recovery of 95.53-104.22% and the relative standard deviation (RSD) less than 5%, indicating the strong application potential.