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Structure-activity relationships for apomorphine congeners. Conformational energies vs. biological activities
1Royal Danish School of Pharmacy, Department of Chemistry BC, Copenhagen.
Journal of Computer-Aided Molecular Design
|July 1, 1987
Abstract:
A series of apomorphine congeners has been studied with respect to their ability to mimic the structural requirements of the dopamine pharmacophore in the potent and stereoselective dopamine receptor agonist (R)-apomorphine. Conformational energies of the mimicking structures calculated by molecular mechanics (MMP2) correlate well with the observed biological activities.