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Updated: Oct 6, 2025

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Published on: May 23, 2021

BCG osteomyelitis: tips for diagnosis.

Yuko Tsujioka^1,2, Taiki Nozaki^3,4, Gen Nishimura^5,6

¹Department of Radiology, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.

Skeletal Radiology

|January 19, 2022

Summary

This summary is machine-generated.

BCG-osteomyelitis in children presents as an indolent disease, distinct from acute pyogenic osteomyelitis. Characteristic imaging findings, especially polyostotic involvement, suggest Mendelian susceptibility to mycobacterial diseases (MSMD).

Keywords:

BCG osteomyelitis Clinical manifestations of BCG osteomyelitis Imaging findings of BCG osteomyelitis Mendelian susceptibility to mycobacterial diseases Mycobacterium bovis Mycobacterium tuberculosis

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Published on: March 14, 2019

Area of Science:

Pediatric Infectious Diseases
Pediatric Radiology
Immunology

Background:

Bacillus Calmette-Guérin (BCG) osteomyelitis is a rare complication of BCG vaccination.
Differentiating BCG osteomyelitis from pyogenic osteomyelitis is crucial for appropriate management.

Purpose of the Study:

To delineate the clinical and imaging features of BCG osteomyelitis.
To compare these characteristics with those of pyogenic osteomyelitis in children.

Main Methods:

Retrospective analysis of clinical and imaging data from 14 children with BCG osteomyelitis (3 with MSMD) and 40 with pyogenic osteomyelitis.
Statistical comparison using Fisher exact and Mann-Whitney U tests.

Main Results:

BCG osteomyelitis is an indolent condition in young children, presenting as a slowly progressive mass.
Imaging reveals a large intraosseous abscess with transphyseal extension, differing from pyogenic osteomyelitis in abscess size, extension pattern, and edema.
Polyostotic involvement in BCG osteomyelitis is indicative of MSMD.

Conclusions:

BCG osteomyelitis should be suspected in young children with insidious osteomyelitis and specific imaging findings.
Polyostotic BCG osteomyelitis strongly suggests underlying MSMD.
Recognizing these distinct features aids in early diagnosis and treatment.