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Updated: Oct 6, 2025

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Do Cytokines Associate Periodontitis with Metabolic Disorders? An Overview of Current Documents
Reza Aref Nezhad1,2, Hossein Motedayyen3, Hossein Roghani-Shahraki4
1Halal Research Center of IRI, FDA, Tehran, Iran.
Abstract:
Periodontitis is an oral chronic inflammatory condition affecting the adult population worldwide. Many microorganisms act as initiators for inducing inflammatory immune responses, which participate in the destruction of connective tissue surrounding the teeth, thereby resulting in tooth loss. Cytokines may have indispensable roles in its pathogenesis by enhancing inflammatory and immune responses. Cytokines can affect the functions of some cells of different tissues, such as the cells of the pancreas, liver, and adipose tissues. Evidence suggests that periodontitis is associated with metabolic disorders like liver cirrhosis, obesity, and diabetes mellitus. Hence, this review focused on determining how cytokines can participate in the correlation of periodontitis with metabolic disorders.
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