[The Liberati's principles ten years later.]

Area of Science:

• Health Research
• Medical Ethics
• Research Governance

Background:

• Alessandro Liberati, founder of the Italian Cochrane Centre, advocated for research addressing patient and family needs.
• His work emphasized open, accessible, and transparent research for all stakeholders.
• Key figures like Sir Iain Chalmers and Paul Glasziou also contribute to these principles.

Purpose of the Study:

• To evaluate the continued relevance of Alessandro Liberati's principles for research.
• To assess the progress made in research governance and patient-centeredness since his passing.

Main Methods:

• Qualitative review of Liberati's contributions and principles.
• Analysis of current research practices in relation to Liberati's ideals.
• Discussion of persistent challenges in research transparency and focus.

Main Results:

• Liberati's core principles of useful, patient-focused research remain highly relevant.
• Significant challenges persist, including a lack of adequate research governance.
• Research remains overly focused on interventions rather than care strategies, with issues of publication bias and conflicts of interest continuing.

Conclusions:

• Liberati's vision for research reform is still needed.
• Urgent action is required to ensure publicly funded research aligns with genuine citizen and patient needs.
• Further efforts are necessary to improve research transparency, reduce bias, and prioritize patient-relevant outcomes.