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Human brain mapping with multithousand-channel PtNRGrids resolves spatiotemporal dynamics.

Youngbin Tchoe1, Andrew M Bourhis1, Daniel R Cleary1,2

  • 1Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA 92093, USA.

Science Translational Medicine
|January 19, 2022
PubMed
Summary
This summary is machine-generated.

Researchers developed platinum nanorod neurophysiological recording grids (PtNRGrids) offering high-resolution brain mapping. These scalable devices provide unprecedented spatial and temporal detail for both clinical applications and brain-machine interface research.

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Area of Science:

  • Neuroscience
  • Materials Science
  • Biomedical Engineering

Background:

  • Electrophysiological devices are crucial for brain mapping and neuromodulation.
  • Current devices face limitations in spatial resolution or cortical coverage.

Purpose of the Study:

  • To develop scalable, high-resolution neurophysiological recording grids.
  • To overcome limitations of existing brain recording technologies.

Main Methods:

  • Developed scalable manufacturing processes for thin-film, multithousand-channel grids using platinum nanorods (PtNRGrids).
  • Utilized a dense electrical connection scheme for reconfigurable arrays.
  • Achieved small (30 μm) contacts with low impedance.

Main Results:

  • PtNRGrids provide high spatial and temporal resolution over large cortical areas.
  • Successfully resolved submillimeter functional organization in rat barrel cortex.
  • Captured fine temporal dynamics from the human cortical surface during grasping tasks.
  • Identified epileptic discharge spread and dynamics at 1-mm resolution in human patients.

Conclusions:

  • PtNRGrids offer a powerful tool for transforming clinical brain mapping.
  • Demonstrated potential for advancing brain-machine interface research.
  • These grids enable detailed analysis of neural activity in both research and clinical settings.