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Updated: Aug 13, 2026

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug
Published on: June 4, 2021
Coronary lithotripsy - a state of the art review
Tara Neleman1, Annemieke C Ziedses des Plantes1, Joost Daemen1
1Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Abstract:
Lesion calcification is frequently encountered during percutaneous coronary intervention and has been directly linked to procedural complications and future cardiac events. Intravascular lithotripsy is a novel balloon-based modality that does not rely on barotrauma or debulking, but converts electrical energy into mechanical energy creating sonic pressure waves that selectively disrupt calcium. The present review provides an overview of its mechanism of action, the available evidence on its safety and efficacy and indications for use.
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