Related Experiment Video

Updated: Oct 6, 2025

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells
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Dimethyl Fumarate Reduces Inflammation in Chronic Active Multiple Sclerosis Lesions

Nicole Zinger1, Gerald Ponath1, Elizabeth Sweeney1

  • 1From the Department of Neurology (N.Z., L.Z., S.A.G.), Weill Cornell Medicine, New York; Department of Neurology (G.P., C.H.L., D.P.), Yale School of Medicine, New Haven, CT; Department of Population Health Sciences (E.S., I.D.), and Department of Radiology (T.D.N., A.D., J.C., Y.W., S.A.G.), Weil Cornell Medicine, New York; Department of Medicine (L.T.), Yale New Haven Hospital, New Haven, CT; Feil Family Brain and Mind Institute (S.A.G.), Weill Cornell Medicine, New York; and Lee Kong Chian School of Medicine (C.H.L.), Nanyang Technological University, Singapore.

Neurology(R) Neuroimmunology & Neuroinflammation
|January 20, 2022
PubMed
Summary

Dimethyl fumarate (DMF) reduces iron in multiple sclerosis (MS) lesions more effectively than glatiramer acetate (GA). DMF also decreases microglial activation and iron content in vitro, suggesting it targets inflammation in MS.

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