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Micro-computed tomographic evaluation of the effect of fluoride agents on white spot lesions: An in vitro study
Sook-Chan Hong1, Dong-Yul Lee2, Yae-Jin Kim3
1Major in Dentistry, Department of Medicine, Graduate School of Korea University, Seoul, Korea.
Objective:
To investigate remineralizing effect of three fluoride regimens on artificially demineralized enamel around orthodontic bracket by analyzing mineral density (MD) acquired from micro-computed tomography (micro-CT).
Methods:
Forty-eight bracket bonded bovine incisors were prepared to create demineralized enamel (DE) surface. The samples were divided into four groups according to the fluoride regimen: 1) no fluoridation, 2) 1.23% acidulated phosphate fluoride (APF) gel, 3) fluoridated toothpaste, and 4) 0.05% sodium fluoride mouthwash. Micro-CT was scanned after demineralization (T0), and 2 weeks (T1) and 4 weeks (T2) of fluoridation.
Results:
APF gel showed highest remineralization of DE during T1-T0 interval among the groups (p < 0.05); followed by toothpaste, mouthwash and no fluoridation. APF gel and toothpaste demonstrated significant increase in MD after 4 weeks of application (p < 0.05).
Conclusions:
Remineralization effects of three fluoride regimens were depicted through micro-CT analysis, of which APF gel was most effective.
