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Keio Uterus Transplantation Research: From Basic Research toward Future Clinical Application
Iori Kisu1, Kouji Banno1, Yusuke Matoba1
1Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
The Keio Journal of Medicine
|January 20, 2022
Summary
Uterus transplantation (UTx) research in non-human primates is advancing, paving the way for clinical applications. This study summarizes essential basic research and activities supporting future uterus transplants in Japan.
Area of Science:
- Reproductive Medicine
- Transplantation Surgery
- Primate Research
Background:
- Uterus transplantation (UTx) offers a potential solution for uterine factor infertility.
- UTx remains experimental, necessitating extensive animal studies before human clinical application.
- Japanese women with infertility could benefit from advancements in UTx.
Purpose of the Study:
- To summarize basic research findings from non-human primate UTx studies.
- To outline activities supporting the clinical implementation of UTx in Japan.
- To address ethical and social considerations for UTx.
Main Methods:
- Accumulation of data from UTx research initiated in 2009.
- Conducting basic animal studies, specifically in non-human primates.
- Engaging in activities to facilitate clinical UTx application.
Main Results:
- Significant progress in UTx research based on non-human primate models.
- Development of a substantial archive of UTx research results.
- Preparation for the imminent clinical application of UTx in Japan.
Conclusions:
- Basic research in non-human primates is crucial for advancing UTx.
- Comprehensive efforts are underway to enable clinical UTx in Japan.
- Future development of UTx research is anticipated with ongoing activities.