Bioaccumulation of Pyraoxystrobin and Its Predictive Evaluation in Zebrafish
Wenzhu Wu1,2, Jing Xu2, Yezhi Dou2
1College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China.
Toxics
|January 20, 2022
Summary
This study investigated pyraoxystrobin bioaccumulation in zebrafish, finding that measured bioconcentration factor (BCF) values closely matched model predictions. This research is crucial for understanding pesticide environmental impact and fish toxicity.
Area of Science:
- Environmental toxicology
- Aquatic toxicology
- Ecotoxicology
Background:
- Pesticide bioaccumulation in aquatic organisms is a significant environmental concern.
- Understanding the bioconcentration of specific pesticides like pyraoxystrobin in fish is vital for risk assessment.
Purpose of the Study:
- To determine the bioaccumulation of pyraoxystrobin in fish.
- To measure the bioconcentration factor (BCF) and clearance rates of pyraoxystrobin in zebrafish.
- To compare experimental BCF values with predictions from common models.
Main Methods:
- A flow-through bioconcentration method was employed using zebrafish.
- Pyraoxystrobin exposure concentrations were maintained at 0.1 μg/L and 1.0 μg/L.
- Bioconcentration factor (BCF), absorption rate constant (K1), clearance rate constant (K2), and half-life (t1/2) were measured.
Main Results:
- Maximum BCF values for pyraoxystrobin in fish were 820.8 and 265.9 at 0.1 μg/L and 1.0 μg/L, respectively.
- Absorption rate constants (K1) were 391.0 d⁻¹ and 153.2 d⁻¹, with maximum enrichment at 12 days.
- Clearance rate constants (K2) were 0.5795 and 0.4721, and half-lives (t1/2) were 3.84 d and 3.33 d.
Conclusions:
- Measured BCF values for pyraoxystrobin in zebrafish were consistent with predictions from established bioconcentration models.
- The findings contribute to a better understanding of pyraoxystrobin's environmental fate and potential risks to aquatic ecosystems.
