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Related Experiment Video

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Electrostatic Interaction-Based High Tissue Adhesive, Stretchable Microelectrode Arrays for the Electrophysiological

Gongwei Tian1, Yan Liu1, Mei Yu2

  • 1MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, National and Local Joint Engineering Laboratory for Synthesis, Transformation and Separation of Extreme Environmental Nutrients, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, P. R. China.

ACS Applied Materials & Interfaces
|January 20, 2022
PubMed
Summary

New stretchable microelectrode arrays (MEAs) use electrostatic adhesion to securely attach to wet tissues, improving electrophysiological signal monitoring. This non-covalent approach enhances biocompatibility and ensures stable, conformal interfaces for reliable signal recording.

Keywords:
adhesive and stretchable microelectrode arrayscompliant adhesionelectrophysiological interfaceelectrostatic interactionhydrogelpolypyrrole

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Area of Science:

  • Biomaterials Science
  • Neuroscience
  • Medical Devices

Background:

  • Stretchable neural microelectrodes are crucial for electrophysiological monitoring but suffer from detachment on wet, dynamic tissues.
  • Existing adhesives often rely on covalent interactions, potentially compromising biocompatibility.
  • Developing robust and biocompatible adhesion is key to advancing neural interface technology.

Purpose of the Study:

  • To fabricate highly conformal, stretchable microelectrode arrays (MEAs) with strong electrostatic adhesion for stable electrophysiological monitoring.
  • To overcome the limitations of current adhesives by utilizing non-covalent interactions for improved biocompatibility.
  • To demonstrate the efficacy of these adhesive MEAs on various wet tissues and for recording physiological signals.

Main Methods:

  • Fabrication of MEAs using polypyrrole (PPy) as the electrode material and a novel hydrogel (PAGMA) as the stretchable substrate.
  • PAGMA hydrogel synthesized via cross-linking and copolymerization of AMPS, gelatin, chitosan, 2-methoxyethyl acrylate, and acrylic acid.
  • Characterization of electrostatic adhesion strength (85 kPa) and material stretchability (100%).

Main Results:

  • Achieved strong and stable electrostatic adhesion (85 kPa) and high stretchability (100%) in the PPy-PAGMA MEAs.
  • Demonstrated conformal integration and stable adhesion on diverse wet, dynamic tissues, including subcutaneous muscle and beating heart.
  • Successfully recorded electrophysiological signals from a rat model, validating the MEA's performance.

Conclusions:

  • Developed a novel electrostatic adhesive MEA (PPy-PAGMA) offering a promising strategy for stable and compliant electrode-tissue interfaces.
  • The non-covalent adhesion mechanism enhances biocompatibility compared to traditional covalent adhesives.
  • These adhesive MEAs represent a significant advancement for long-term, reliable electrophysiological signal monitoring in dynamic biological environments.