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Updated: Jun 27, 2026

Identification of Circular RNAs using RNA Sequencing
Published on: November 14, 2019
Circular RNA circYPEL2: A Novel Biomarker in Cervical Cancer
Xinyang Zhang1, Siqi Yang1, Wenbo Chen1
1School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
Abstract:
Cervical cancer (CC) is one of the most threatening diseases in women. Circular RNAs (circRNAs) have been reported to be cancer hallmarks, but typical circRNAs in CC were rarely indicated. Through high-throughput sequencing in CC and normal cervix tissues, circYPEL2 (hsa_circ_0005600) was proposed as a candidate circRNA. CircYPEL2 exhibited significantly high expression in CC tissue and strong stability in CC cell lines. Furthermore, knockdown and overexpression of circYPEL2 indicated the potential involvement in CC proliferation, migration and invasion. Finally, the downstream regulatory genes of circYPEL2 were investigated by knockdown experiment in CC cell lines with high-throughput sequencing. In summary, our work identified circYPEL2 as a potential biomarker for clinical research of cervical cancer.
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