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Updated: Oct 6, 2025
10:09
Characterization of Immune Cell-derived Extracellular Vesicles and Studying Functional Impact on Cell Environment
Published on: June 2, 2020
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Dynamic Intercell Communication between Glioblastoma and Microenvironment through Extracellular Vesicles
Gloria Krapež1, Katarina Kouter1, Ivana Jovčevska1
1Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, SI-1000 Ljubljana, Slovenia.
Biomedicines
|January 21, 2022
Summary
Glioblastoma, a common brain tumor, often recurs and resists treatment. Extracellular vesicles (EVs) play a role in tumor progression and resistance but also offer potential as a novel therapeutic delivery system.
Area of Science:
- Neuro-oncology
- Cancer Biology
- Biochemistry
Background:
- Glioblastoma is the most common and aggressive primary brain tumor, characterized by poor survival rates and limited treatment options.
- Recurrent glioblastomas frequently develop radio- and chemoresistance, necessitating novel therapeutic strategies.
- Tumor malignancy is influenced by the tumor microenvironment, with extracellular vesicles (EVs) emerging as key intercellular communicators.
Purpose of the Study:
- To explore the multifaceted role of extracellular vesicles (EVs) in glioblastoma biology.
- To investigate the involvement of EVs in glioblastoma progression, therapy resistance, and immune modulation.
- To evaluate the potential of EVs as a therapeutic delivery platform for glioblastoma.
Main Methods:
- Analysis of glioblastoma gene mutations and expression profiles.
- Investigation of extracellular vesicle (EV) cargo and function.
- Assessment of EV interactions with the tumor microenvironment and host immune system.
- Evaluation of EV-mediated drug delivery across the blood-brain barrier.
Main Results:
- Extracellular vesicles (EVs) are identified as critical mediators in glioblastoma, influencing tumor cell survival, metabolism, initiation, and progression.
- EVs contribute to the development of therapy resistance in glioblastoma.
- EVs modulate the tumor immune microenvironment and interact with the host immune system.
- EVs demonstrate potential for therapeutic applications due to their ability to cross the blood-brain barrier and be engineered for targeted delivery.
Conclusions:
- Extracellular vesicles (EVs) play a significant role in glioblastoma pathogenesis and treatment resistance.
- EVs represent a promising therapeutic avenue for glioblastoma, offering targeted delivery of therapeutic agents across the blood-brain barrier.
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