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Updated: Oct 6, 2025

Tools to Study the Role of Architectural Protein HMGB1 in the Processing of Helix Distorting, Site-specific DNA Interstrand Crosslinks

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HMGB-1 in Psoriasis.

Marco Casciaro¹, Eleonora Di Salvo², Sebastiano Gangemi¹

¹School and Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.

|January 21, 2022

Summary

This summary is machine-generated.

High mobility group box 1 (HMGB1) levels are elevated in psoriasis patients, contributing to systemic inflammation. Blocking HMGB1 shows promise as a therapeutic strategy for psoriasis and other immune-related diseases.

Keywords:

HMGB-1 alarmin biologic immune system inflammation monoclonal psoriasis skin therapy

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Published on: September 20, 2017

Area of Science:

Immunology
Dermatology
Molecular Biology

Background:

Psoriasis is a chronic inflammatory skin condition characterized by enhanced keratinocyte proliferation and immune cell infiltration.
Systemic inflammation and dysregulation of apoptosis are key features of psoriasis.
High mobility group box 1 (HMGB1), an alarmin released during cellular damage, plays a role in inflammatory conditions.

Purpose of the Study:

To evaluate HMGB1 levels in psoriasis patients.
To investigate the potential of blocking HMGB1 as a therapeutic strategy for psoriasis.
To correlate HMGB1 levels with disease severity and other inflammatory markers.

Main Methods:

Measurement of HMGB1 levels in lesional skin and serum of psoriasis patients.
Assessment of correlation between HMGB1 levels, other pro-inflammatory markers, alarmins, and the Psoriasis Area and Severity Index (PASI) score.
Evaluation of the efficacy of HMGB1 blockade through standard therapies, biological treatments, and monoclonal antibodies.

Main Results:

Psoriasis patients exhibited significantly increased levels of HMGB1 in both lesional skin and serum.
Elevated HMGB1 levels were often linked to other pro-inflammatory markers and alarmins.
In most cases, these parameters correlated with the PASI score, indicating disease severity.
Blocking HMGB1 demonstrated effectiveness in ameliorating psoriasis symptoms.

Conclusions:

HMGB1 is a significant factor in psoriasis pathogenesis, acting as an alarmin that exacerbates inflammation.
Targeting HMGB1 through blockade therapies presents a promising therapeutic avenue for psoriasis.
HMGB1 blockade offers a novel approach for managing immune-related diseases, expanding therapeutic possibilities.