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Updated: Oct 6, 2025

Methods to Study Lipid Alterations in Neutrophils and the Subsequent Formation of Neutrophil Extracellular Traps
Published on: March 29, 2017
Oxysterols in the Immune Response to Bacterial and Viral Infections
Cheng Xiang Foo1, Stacey Bartlett1, Katharina Ronacher1,2
1Translational Research Institute, Mater Research Institute, The University of Queensland, Brisbane, QLD 4102, Australia.
Abstract:
Oxidized cholesterols, the so-called oxysterols, are widely known to regulate cholesterol homeostasis. However, more recently oxysterols have emerged as important lipid mediators in the response to both bacterial and viral infections. This review summarizes our current knowledge of selected oxysterols and their receptors in the control of intracellular bacterial growth as well as viral entry into the host cell and viral replication. Lastly, we briefly discuss the potential of oxysterols and their receptors as drug targets for infectious and inflammatory diseases.
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