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Coronary Artery Disease and Cancer: Treatment and Prognosis Regarding Gender Differences

Stefan A Lange1, Holger Reinecke1

  • 1Department of Cardiology I-Coronary and Peripheral Vascular Disease, Heart Failure, Cardiol, University Hospital Muenster, D-48149 Muenster, Germany.

Cancers
|January 21, 2022
PubMed

Insights

Women with myocardial infarction face worse outcomes, and cancer patients are often excluded from cardiology studies. This review examines coronary artery disease in cancer patients, focusing on sex-specific differences.

Area of Science:

  • Cardiology
  • Oncology
  • Sex-Specific Medicine

Background:

  • Cardiovascular disease and cancer are leading causes of death globally.
  • Women with myocardial infarction have poorer clinical outcomes compared to men.
  • Cancer patients are underrepresented in cardiovascular research, limiting understanding of co-existing conditions.

Purpose of the Study:

  • To review the limited information on coronary artery disease (CAD) in cancer patients.
  • To investigate sex-specific differences in the treatment and prognosis of CAD among cancer patients.
  • To focus on major cancers including breast, colon, lung, prostate, and hematological malignancies.

Main Methods:

  • Systematic review of studies involving patients with both coronary artery disease and cancer.
  • Analysis of data from over 27 million patients.
  • Focus on sex-specific outcomes and management strategies.

Main Results:

  • Limited data exists on CAD outcomes in cancer patients, especially women.
  • Sex-specific differences in treatment and prognosis for CAD in cancer patients are largely unknown.
  • Current management strategies for these patients are often based on empiric evidence.

Conclusions:

  • There is a critical need for more research on cardiovascular disease in cancer patients.
  • Understanding and addressing sex-specific differences in CAD outcomes is crucial for this population.
  • Improved evidence-based guidelines are needed for managing comorbid CAD and cancer.

Keywords:
cancercardiovascular diseasehematological malignanciesmortalitypercutaneous coronary interventionprognosissex-specific differencestreatment

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