Related Experiment Video

Updated: Oct 6, 2025

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

14.7K

Anticoagulation Prior to COVID-19 Infection Has No Impact on 6 Months Mortality: A Propensity Score-Matched Cohort

Marcin Protasiewicz1,2, Konrad Reszka2, Wojciech Kosowski1,2

  • 1Institute of Heart Diseases, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland.

Journal of Clinical Medicine
|January 21, 2022
PubMed

Insights

Anticoagulant treatment before coronavirus disease 2019 (COVID-19) infection did not significantly impact mortality or clinical outcomes in hospitalized patients. This study found no protective benefit from prior antithrombotic therapy for COVID-19 patients.

Area of Science:

  • Internal Medicine
  • Cardiology
  • Infectious Diseases

Background:

  • Coronavirus disease 2019 (COVID-19) is associated with a high incidence of thromboembolic events.
  • The potential impact of pre-existing anticoagulation on COVID-19 patient outcomes remains an area of investigation.

Purpose of the Study:

  • To evaluate the effect of anticoagulant treatment prior to COVID-19 infection on clinical profile and mortality.
  • To compare outcomes between COVID-19 patients with and without prior anticoagulant therapy.

Main Methods:

  • Retrospective analysis of medical records for laboratory-confirmed SARS-CoV-2 infection.
  • Propensity score matching (PSM) to compare 236 patients on prior anticoagulant treatment (AT group) with 236 patients without (no AT group).
  • 180-day observation period for mortality and clinical outcomes.

Main Results:

  • No statistically significant difference in mortality rates between the AT group (38.5%) and the no AT group (41.1%) (p = 0.51).
  • Comparable rates of intensive care unit admission, intubation, mechanical ventilation, catecholamine use, and bleeding between the two groups.
  • No significant differences observed in key clinical outcomes or adverse events.

Conclusions:

  • Antithrombotic treatment prior to COVID-19 infection does not appear to offer protection against morbidity or mortality in hospitalized patients.
  • Pre-existing anticoagulation therapy did not alter the clinical course or survival of patients admitted with COVID-19.

Keywords:
6 months outcomeCOVID-19SARS-CoV-2anticoagulationmorbiditymortalitythromboembolic complications

More Related Videos

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation23:33

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

83.9K
Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood11:17

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Published on: October 12, 2012

14.0K

Related Concept Videos

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.4K
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
46
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
987
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.7K
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
188
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
63