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Updated: Oct 6, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

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Oncogenic Role of Exosomal Circular and Long Noncoding RNAs in Gastrointestinal Cancers

Ba Da Yun1, Ye Ji Choi1, Seung Wan Son1

  • 1Department of Biomedical Science and Research, Institute for Bioscience & Biotechnology, Hallym University, Chunchon 24252, Korea.

International Journal of Molecular Sciences
|January 21, 2022
PubMed

Insights

Circular RNAs (circRNAs) and long noncoding RNAs (lncRNAs) in exosomes are key players in gastrointestinal cancers. Understanding these exosomal noncoding RNAs (ncRNAs) is vital for developing new cancer therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Circular RNAs (circRNAs) and long noncoding RNAs (lncRNAs) show altered expression in gastrointestinal cancers.
  • These noncoding RNAs (ncRNAs) influence cellular activities through interactions with microRNAs and proteins.
  • Exosomes secreted by cancer cells carry circRNAs and lncRNAs, mediating intercellular communication.

Purpose of the Study:

  • To review the functions and characteristics of oncogenic circRNAs and lncRNAs found in exosomes.
  • To highlight the role of exosomal ncRNAs in the cancer microenvironment.
  • To provide a foundation for novel therapeutic strategies against gastrointestinal malignancies.

Main Methods:

  • Literature review of studies on circRNAs and lncRNAs in gastrointestinal cancers.
  • Analysis of exosomal cargo and its biological implications.
  • Synthesis of current knowledge on ncRNA-mediated cell-cell communication in cancer.

Main Results:

  • Exosomal circRNAs and lncRNAs are involved in critical cancer processes like angiogenesis, metastasis, immune evasion, and drug resistance.
  • These exosomal ncRNAs facilitate epithelial-to-mesenchymal transition.
  • The composition and function of exosomal ncRNAs contribute significantly to the tumor microenvironment.

Conclusions:

  • Exosomal circRNAs and lncRNAs are crucial mediators of intercellular communication in gastrointestinal cancers.
  • Targeting exosomal ncRNAs presents a promising avenue for developing innovative cancer therapies.
  • Further research into the specific roles of these ncRNAs is essential for advancing treatment strategies.
Keywords:
circular RNAexosomegastrointestinal cancerlong noncoding RNA

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