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Clinicopathologic Features of Lymphoproliferative Neoplasms Involving the Liver
I Chiang1, Ren-Ching Wang1,2, Ying-Ching Lai1
1Department of Pathology and Laboratory Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan.
Medicina (Kaunas, Lithuania)
|January 21, 2022
Summary
Primary hepatic lymphoproliferative neoplasms (PHL) and secondary hepatic lymphoproliferative neoplasms (SHL) share similar features, but SHL patients have a significantly poorer prognosis with only a 3-month median survival.
Area of Science:
- Hepatology
- Oncology
- Hematology
Background:
- Primary hepatic lymphoproliferative neoplasms (PHL) are rare liver conditions.
- Distinguishing PHL from secondary hepatic lymphoproliferative neoplasms (SHL) is crucial for patient outcomes.
Purpose of the Study:
- To present clinicopathological characteristics of PHL.
- To compare PHL with SHL in a Taiwanese tertiary medical center.
Main Methods:
- Retrospective analysis of 36 patients with liver lymphoproliferative neoplasms (2004-2018).
- Review of demographic, clinical, radiological, and histopathological data.
- Comparison of PHL and SHL patient groups.
Main Results:
- Diffuse large B-cell lymphoma was the predominant subtype in both PHL (67%) and SHL (40%).
- No significant differences in clinical, laboratory, or radiological features between PHL and SHL.
- SHL patients had a significantly shorter median survival (3 months) compared to PHL (not reached).
Conclusions:
- PHL and SHL exhibit overlapping clinical and radiological profiles.
- SHL patients face extremely poor prognoses, necessitating urgent therapeutic development.
- Further research into effective treatments for SHL is critical.
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