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Treatment of multiple intestinal helminthiasis with oxantel and pyrantel
Insights
This study shows that a combination of oxantel pamoate and pyrantel pamoate effectively treats multiple intestinal worm infections in children. The treatment significantly reduced worm presence and egg counts, even when a complete cure wasn't achieved.
Area of Science:
- Pediatric Medicine
- Infectious Diseases
- Parasitology
Background:
- Intestinal helminthiasis is a common parasitic infection in children worldwide.
- Multiple helminth infections can lead to significant health issues and impaired development.
- Effective and safe treatment options are crucial for managing pediatric helminthiasis.
Purpose of the Study:
- To evaluate the efficacy of a combined oxantel pamoate and pyrantel pamoate treatment.
- To assess the cure rates for ascariasis, trichuriasis, and hookworm infections in elementary school children.
- To determine the impact of the treatment on overall helminth burden and egg counts.
Main Methods:
- A cohort of 32 elementary school children with multiple intestinal helminthiasis was treated.
- The treatment involved a combination of oxantel pamoate and pyrantel pamoate.
- Dosage was 15-20mg/kg body weight of each drug, administered daily for 3 consecutive days.
Main Results:
- High cure rates were observed: 96.7% for ascariasis and 84.4% for trichuriasis and hookworm infections.
- Complete cure for all three helminth species was achieved in 68.7% of children.
- Non-complete cures showed a marked reduction in egg counts and the presence of only one helminth species.
Conclusions:
- The combination of oxantel pamoate and pyrantel pamoate is highly effective for treating multiple intestinal helminth infections in children.
- The treatment demonstrates significant efficacy in reducing parasitic load and associated symptoms.
- This therapeutic approach offers a promising solution for pediatric helminthiasis management.
Abstract:
32 elementary school children were treated for multiple intestinal helminthiasis (ascariasis, trichuriasis and hookworm infections) with a combination of the pamoate salts of oxantel and pyrantel in a dose of 15 to 20mg/kg body weight of each in 1 daily dose for 3 consecutive days. The cure rate for ascariasis was 96.7%, and 84.4% for both trichuriasis and hookworm infections. 68.7% were completely cured of all 3 helminths. However, among those not completely cured, only 1 species of the previous 3 infecting helminths was present after treatment and then with a very marked reduction in egg count.