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Disrupting GPCR Complexes with Smart Drug-like Peptides

Maria Gallo1, Sira Defaus1, David Andreu1

  • 1Department of Experimental and Health Sciences, Pompeu Fabra University, Barcelona Biomedical Research Park, 08003 Barcelona, Spain.

Pharmaceutics
|January 21, 2022
PubMed
Summary

G protein-coupled receptors (GPCRs) form complexes, and peptides targeting these structures can disrupt their function. Researchers are developing drug-like versions of these therapeutic peptides to improve their effectiveness.

Keywords:
GPCR oligomerscyclic peptidesnon-natural amino acidspeptide therapeuticsretro-enantiotransmembrane peptides

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