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Rigidity transitions in development and disease.

Edouard Hannezo1, Carl-Philipp Heisenberg1

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Summary
This summary is machine-generated.

Biological systems may undergo rigidity transitions, impacting development and disease. This review explores the regulation and physiological roles of these potential tissue rigidity changes.

Keywords:
criticalitymorphogenesismultiscale modellingrigidity transitiontissue mechanics

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Area of Science:

  • Biophysics
  • Developmental Biology
  • Cell Biology

Background:

  • Rigidity and jamming transitions are well-established in physics and material science.
  • Their significance in biological processes like development and disease is a recent area of study.
  • The ability of biological systems to rapidly alter material properties via these transitions is a compelling hypothesis.

Purpose of the Study:

  • To review recent theoretical and experimental progress on rigidity and jamming transitions in biological systems.
  • To focus on the regulation mechanisms and physiological relevance of potential tissue rigidity transitions.
  • To discuss the ongoing debate regarding the occurrence and importance of these transitions in biology.

Main Methods:

  • Review of recent theoretical advancements.
  • Analysis of experimental findings from the past few years.
  • Synthesis of literature on tissue rigidity and jamming phenomena.

Main Results:

  • Recent research highlights the potential for biological systems to exhibit rigidity and jamming transitions.
  • Evidence is accumulating on the regulation of these transitions within different biological contexts.
  • The precise physiological roles and extent of these transitions remain subjects of active investigation and debate.

Conclusions:

  • Tissue rigidity transitions offer a plausible mechanism for rapid and significant changes in biological material properties.
  • Further research is needed to definitively establish the occurrence, regulation, and functional importance of these transitions in various biological processes.
  • Understanding these transitions could provide new insights into development, homeostasis, and disease progression.