Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

228
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
228
RNA-seq03:21

RNA-seq

10.5K
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
10.5K
Genomics02:02

Genomics

37.8K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
37.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A longitudinal single-cell atlas to predict outcome and toxicity after BCMA-directed CAR T cell therapy in multiple myeloma.

Cancer cell·2025
Same author

Single-cell multiomic dissection of response and resistance to chimeric antigen receptor T cells against BCMA in relapsed multiple myeloma.

Nature cancer·2024
Same author

Time-resolved assessment of single-cell protein secretion by sequencing.

Nature methods·2023
Same author

Antibody-Oligonucleotide Conjugation Using a SPAAC Copper-Free Method Compatible with 10× Genomics' Single-Cell RNA-Seq.

Methods in molecular biology (Clifton, N.J.)·2022
Same author

Twenty-seven cases of pineal parenchymal tumours of intermediate differentiation: mitotic count, Ki-67 labelling index and extent of resection predict prognosis.

Journal of neurology, neurosurgery, and psychiatry·2015
Same author

The Neutrophil-to-Lymphocyte Ratio Correlates with Age in Patients with Papillary Thyroid Carcinoma.

ORL; journal for oto-rhino-laryngology and its related specialties·2015
Same journal

Revolutionizing Transcriptomics: From Single-Cell Insights to RNA-based Interventions.

SLAS technology·2026
Same journal

Smartphone-based colorimetric glucose biosensor using peroxidase-like activity of bimetallic catalyst supported onto graphitic carbon nitride nanosheets.

SLAS technology·2026
Same journal

XVCF: Exquisite visualization of VCF data from genomic experiments.

SLAS technology·2026
Same journal

EasyPip: An equipment-agnostic software application to transform automated liquid handlers into efficient walk-up tools for routine plate-based pipetting.

SLAS technology·2026
Same journal

Identification of ubiquitination-related biomarkers in osteoarthritis: Combining transcriptome and Mendelian randomization analysis.

SLAS technology·2026
Same journal

Miniaturization of a Lumit p-ERK immunoassay for cell-based high-throughput screening of a chemogenetic small-molecule library.

SLAS technology·2026
See all related articles

Related Experiment Video

Updated: Oct 6, 2025

An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing
10:00

An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing

Published on: May 23, 2018

17.9K

Complex biological questions being addressed using single cell sequencing technologies.

Tao Yu1, Jonathan Scolnick2

  • 1Healthy Longevity Translational Research Program, Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 117597 Singapore, Singapore.

SLAS Technology
|January 21, 2022
PubMed
Summary
This summary is machine-generated.

Scientists are developing advanced single-cell analysis tools to understand complex biological processes. This review explores the evolution of these tools and future directions for single-cell biology research.

More Related Videos

Multiplexed Single Cell mRNA Sequencing Analysis of Mouse Embryonic Cells
08:30

Multiplexed Single Cell mRNA Sequencing Analysis of Mouse Embryonic Cells

Published on: January 7, 2020

13.4K
A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
09:34

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

6.8K

Related Experiment Videos

Last Updated: Oct 6, 2025

An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing
10:00

An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing

Published on: May 23, 2018

17.9K
Multiplexed Single Cell mRNA Sequencing Analysis of Mouse Embryonic Cells
08:30

Multiplexed Single Cell mRNA Sequencing Analysis of Mouse Embryonic Cells

Published on: January 7, 2020

13.4K
A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
09:34

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

6.8K

Area of Science:

  • Single-cell biology
  • Molecular biology
  • Biotechnology

Background:

  • Understanding multicellular processes requires single-cell resolution.
  • Historical advancements include immunohistochemistry and multi-parametric cytometry.
  • Recent innovations enable multi-omic data acquisition from individual cells.

Purpose of the Study:

  • To review the motivations behind developing single-cell analysis tools.
  • To provide historical context for single-cell research.
  • To discuss future directions and desired tools in single-cell biology.

Main Methods:

  • Review of historical and recent technological developments in single-cell analysis.
  • Exploration of multi-omic data acquisition techniques.
  • Analysis of motivations driving tool development.

Main Results:

  • Single-cell analysis has evolved significantly over the past century.
  • Technological advancements allow simultaneous multi-omic data collection.
  • There is a continuous drive for more comprehensive single-cell insights.

Conclusions:

  • The quest for single-cell resolution is a long-standing biological goal.
  • Technological innovation is key to advancing single-cell biology.
  • Future tools will likely enable even deeper and more integrated single-cell analyses.