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Updated: Oct 6, 2025
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Acute macular neuroretinopathy in dengue virus serotype 1
Gabriel A Guardiola1, Victor M Villegas2,3, Vanessa Cruz-Villegas2
1Universidad Central del Caribe School of Medicine, PO BOX 60327, Bayamon, 00960-6032 , Puerto Rico.
Purpose:
To report a case of acute macular neuroretinopathy (AMN) associated with dengue virus serotype 1 infection.
Observation:
An 18-year-old Puerto Rican female was evaluated due to painless paracentral scotomas in each eye that developed after being hospitalized for dengue fever a week before. Clinical examination and multimodal imaging revealed bilateral hypopigmented macular lesions, hyperreflectivity at the outer nuclear and photoreceptor layer, and reduced flow signal in the deep capillary plexus. Additionally, hypoautofluorescent parafoveal lesions were found in the left eye. AMN was diagnosed. Two-month follow-up after the initial evaluation showed resolution of symptoms but persistence of some findings on optical coherence tomography.
Conclusions And Importance:
Patients with dengue virus serotype 1 may develop paracentral scotomas with classic AMN findings and obtain complete symptomatic recovery without treatment.
