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Update on COVID-19 vaccination in pediatric solid organ transplant recipients

Daniel E Dulek1, Monica I Ardura2, Michael Green3

  • 1Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Pediatric Transplantation
|January 21, 2022
PubMed

Insights

COVID-19 vaccines are safe and effective for children, including those aged 5-11. However, more research is needed on vaccine effectiveness in pediatric solid organ transplant recipients to optimize their protection against SARS-CoV-2.

Area of Science:

  • Immunology
  • Vaccinology
  • Pediatric Medicine

Background:

  • COVID-19 vaccination significantly reduces SARS-CoV-2 infection and severe disease in immunocompetent individuals.
  • Available data confirm the safety, immunogenicity, and effectiveness of various COVID-19 vaccine formulations.
  • The Pfizer-BioNTech mRNA vaccine has demonstrated safety and efficacy in children as young as 5 years, with regulatory approvals for those aged 5-11 in the US.

Purpose of the Study:

  • To review current COVID-19 vaccine data for pediatric solid organ transplant (SOT) recipients.
  • To address specific issues related to COVID-19 vaccination in this vulnerable population.
  • To highlight the need for further research in pediatric transplantation.

Main Methods:

  • Review of current COVID-19 vaccine data.
  • Focus on studies relevant to pediatric SOT recipients.
  • Analysis of immunogenicity, safety, and efficacy data.

Main Results:

  • An overview of COVID-19 vaccine immunogenicity, safety, and efficacy is presented.
  • Data specific to pediatric SOT recipients are highlighted.
  • A significant lack of data remains concerning pediatric transplantation.

Conclusions:

  • Further studies are required to understand T-cell and antibody kinetics post-vaccination in pediatric SOT recipients.
  • Determining the optimal vaccine schedule for pediatric SOT recipients is crucial.
  • Increased vaccine acceptability, uptake, and global availability are essential to protect pediatric SOT recipients from COVID-19.
Abstract

Keywords:
COVID-19SARS-CoV-2childrenimmunizationsolid organ transplantationvaccinationvaccine

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