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Predictive Value of CHA2DS2 -VASc-HSF Score for Severity of Acute Coronary Syndrome

Jingyi Liu1, Yang Ma1, Haiwei Bu1

  • 1117914Chengde Medical University Affiliated Hospital, Chengde, HeBei, 067000, China.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|January 21, 2022
PubMed

Insights

The CHA2DS2-VASc-HSF score effectively predicts acute coronary syndrome (ACS) severity and serves as an independent risk factor for ACS. This novel score offers valuable insights into coronary artery disease (CAD) progression.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Risk Stratification

Background:

  • CHADS2 and CHA2DS2-VASc scores are established for thromboembolism risk in non-valvular atrial fibrillation.
  • These scores have demonstrated utility in evaluating coronary artery disease (CAD) severity.
  • The CHA2DS2-VASc-HSF score is a novel metric assessing atherosclerosis and its association with CAD severity.

Purpose of the Study:

  • To investigate the association between the CHA2DS2-VASc-HSF score and acute coronary syndrome (ACS) severity.
  • To assess ACS severity using the Gensini score and the number of affected coronary vessels.
  • To compare the diagnostic value of CHADS2, CHA2DS2-VASc, and CHA2DS2-VASc-HSF scores for predicting ACS.

Main Methods:

  • A cohort of 2367 inpatients, including 2030 with ACS and 337 without CAD, were enrolled.
  • Logistic regression models and receiver operating characteristic (ROC) curve analyses were employed.
  • Risk factors for ACS were analyzed, and scores were compared between ACS and control groups.

Main Results:

  • CHADS2, CHA2DS2-VASc, and CHA2DS2-VASc-HSF scores were significantly higher in the ACS group.
  • The CHA2DS2-VASc-HSF score emerged as an independent risk factor for ACS after adjusting for traditional CAD risk factors (OR 1.401, P < 0.05).
  • The CHA2DS2-VASc-HSF score demonstrated predictive value for ACS severity.

Conclusions:

  • The CHA2DS2-VASc-HSF score is a valuable tool for assessing atherosclerosis and predicting ACS severity.
  • This score offers improved risk stratification for patients with suspected or confirmed coronary artery disease.
  • The CHA2DS2-VASc-HSF score shows promise in clinical practice for managing patients with cardiovascular conditions.

Keywords:
CHA2DS2-VASc-HSF scoreGensini scoreacute coronary syndromediagnosis

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