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Cost-Effective Use of the Protein S Algorithm in Thrombophilia Testing
Marian A Rollins-Raval1, John V Mitsios2, Richard A Marlar1
1Department of Pathology, University of New Mexico Health Sciences Center, TriCore Reference Laboratories, Albuquerque, NM.
The Journal of Applied Laboratory Medicine
|January 21, 2022
Summary
The International Society for Hemostasis and Thrombosis (ISTH) evidence-based algorithm for Protein S (PS) testing improves diagnostic efficiency and reduces costs. Implementing this algorithm saves 31%-60% compared to traditional PS testing methods.
Area of Science:
- Clinical Chemistry
- Hematology
- Thrombosis Research
Background:
- Protein S (PS) testing for thrombophilia is complex, involving multiple plasma assays.
- Current testing algorithms can lead to misdiagnosis and resource waste.
Purpose of the Study:
- To compare the ISTH evidence-based algorithm with non-evidence-based schemes for Protein S testing.
- To demonstrate the diagnostic efficiency and cost-effectiveness of the ISTH algorithm.
Main Methods:
- Comparative analysis of the ISTH evidence-based algorithm against common, non-evidence-based Protein S testing strategies.
- Evaluation of diagnostic efficiency, patient care improvements, and laboratory cost savings.
Main Results:
- The evidence-based algorithm demonstrated significant cost savings of 31%-60% compared to other testing modalities.
- Utilizing the ISTH algorithm limits wasteful practices in thrombophilia evaluations.
Conclusions:
- The ISTH evidence-based algorithm offers a more efficient and cost-effective approach to Protein S testing.
- Appropriate testing methods enhance diagnostic yield while conserving resources.
