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Updated: Oct 6, 2025
Bridging the Bio-Electronic Interface with Biofabrication
Published on: June 6, 2012
An innovative electrically conductive biopolymer based on poly(β-cyclodextrin) towards recognition of ascorbic acid
Milad Baghal Behyar1,2, Houman Kholafazad-Kordasht3, Soodabeh Hassanpour4
1Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Abstract:
In this study, a sensitive platform was designed for the electrocatalytical oxidation and recognition of ascorbic acid (AA) based on poly(β-cyclodextrin) modified glassy carbon electrode (p(β-CD-GCE). Electropolymerization of β-CD on the surface of GCE was performed on the potential range of -1 to 1.5 V. So, a novel biopolymer was prepared on the surface of GCE towards sensitive recognition of AA in human plasma samples. The developed platform has good sensitivity and accuracy for electrooxidation and detection of AA with lower limit of quantification (LLOQ) of 1 nM and linear range of 1 nM to 100 mM. Moreover, the designed electrochemical sensor was employed for the analysis of AA on human plasma samples with high sensitivity. Based on advantages of p(β-CD) prepared by electropolymerization procedure (green, fast, homogeny, and efficient eletrocatalytical behaviour), this conductive biopolymer showed excellent analytical behaviour towards electrooxidation of AA. It is expected that the prepared polymeric interface is able to use in the analysis of biological species in clinical samples.
