Related Experiment Video
Updated: Oct 6, 2025

Viral Transgene Expression in Rodent Hearts and the Assessment of Cardiac Arrhythmia Risk
Published on: July 27, 2022
[Role of TREM-1 in cardiovascular diseases]
Marie Vandestienne1, Jérémie Joffre2, Jérémie Lemarié3
1Université de Paris, Inserm U970, PARCC (Paris Cardiovascular Research Center), Paris, France.
Abstract:
The innate immune system plays a crucial role in cardiovascular disease initiation, progression and complications. TREM-1, a receptor mainly expressed by myeloid cells, orchestrates inflammatory responses and amplifies cytokine and chemokine production as well as oxidative burst. Recent experimental studies have demonstrated that TREM-1 blockade is protective, limiting atherosclerosis and abdominal aortic aneurysm development, as well as adverse tissue remodeling after cardiac or cerebral ischemic injuries. Plasma soluble TREM-1 level is a promising biomarker in patients with cardiovascular diseases for risk stratification, paving the way for personalized immune-modulatory approaches.
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