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Ocular Behçet disease and COVID-19
Massimo Accorinti1, Priscilla Manni1, Lorenzo Sampalmieri1
1Ocular Immunovirology Service - Sapienza 9311University of Rome, Rome, Italy.
European Journal of Ophthalmology
|January 21, 2022
Summary
Patients with Behçet disease and ocular involvement (OBD) have a higher risk of SARS-CoV-2 infection. This COVID-19 infection typically presents mildly and does not worsen ocular inflammation in OBD patients.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Rheumatology
Background:
- Behçet disease (BD) is a multisystemic inflammatory disorder.
- Ocular involvement in BD (OBD) can lead to significant vision impairment.
- The impact of SARS-CoV-2 infection on patients with OBD requires investigation.
Purpose of the Study:
- To determine the prevalence of SARS-CoV-2 infection in patients with ocular BD.
- To assess the influence of SARS-CoV-2 infection on the course of ocular inflammation in OBD.
Main Methods:
- A cohort of patients with ocular BD from the Lazio region of Italy was studied.
- Prevalence of SARS-CoV-2 infection was compared between OBD patients and the general population.
Main Results:
- SARS-CoV-2 infection was detected in 12.3% of 54 OBD patients, significantly higher than the 3.84% in the general population (p<0.001).
- COVID-19 symptoms were generally mild, with one hospitalization for pneumonia.
- No uveitis relapses occurred during infection or a 6-month follow-up.
Conclusions:
- Ocular BD appears to be a risk factor for SARS-CoV-2 infection.
- SARS-CoV-2 infection in OBD patients usually follows a mild clinical course.
- COVID-19 infection does not appear to negatively affect the course of uveitis in Behçet disease.
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