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Updated: Oct 5, 2025

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A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
Published on: September 9, 2016
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Expeditious assembly of biuret-guanidine derivatives via the catalyst-free transformation
Zhen Yang1,2, Ting-Ting Cao1,3, Yun-Fang Sun3
1Department of Traditional Chinese Medicine, Jilin Agricultural University, Changchun 130118, China.
Journal of Asian Natural Products Research
|January 24, 2022
Abstract:
We disclose a mild and practical catalyst-free transformation for the expeditious construction of biuret-guanidine derivatives using aromatic isocyanates. This synthetic transformation is featured with mild reaction conditions and high efficiency.

