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Myocardial glutathione alterations in acute coronary occlusion in the dog
F J Romero1, A Montoro, G T Sáez
1Departamento de Fisiología, Facultad de Medicina, Universitat de Valéncia, Spain.
Free Radical Research Communications
|January 1, 1987
Abstract:
Glutathione (GSH) decreases in dog myocardium upon acute coronary occlusion when compared with sham-operated dogs. Total glutathione content (GSHeq = GSH + 2GSSG) remains unchanged throughout the experiment (6 h after surgery) in both sham- and acute coronary occlusion-operated dogs. GSSG and GSH/GSSG ratio increases and decreases respectively in all animals but tends to reach the normal value after 6 h in sham-operated dogs. Both parameters (GSSG and GSH/GSSG ratio) remain altered in acute coronary occlusion-operated ones. This alteration of glutathione status in ischemic myocardium is discussed.