Magnesium Citrate Capsules in Colonoscopy Preparation: A Randomized Controlled Trial

Area of Science:

• Gastroenterology
• Colorectal Cancer Screening
• Medical Device Development

Background:

• Screening colonoscopies are crucial for colorectal cancer prevention.
• Traditional liquid bowel preparations are often poorly tolerated by patients.
• Novel, low-cost alternatives are needed to improve patient compliance.

Purpose of the Study:

• To evaluate the adequacy and tolerability of a novel low-cost colonoscopy preparation.
• To compare a magnesium citrate capsule and bisacodyl (MCCB) preparation with a standard liquid preparation.
• To assess patient satisfaction with the MCCB preparation.

Main Methods:

• A single-center, assessor-blinded, randomized controlled trial was conducted.
• 51 patients undergoing screening colonoscopies were randomized to receive either GoLYTELY or MCCB.
• Adequate colon cleanliness was assessed using the Boston Bowel Preparation Scale; patient satisfaction was measured via questionnaire.

Main Results:

• 100% of patients in both preparation groups achieved adequate colon cleanliness.
• The MCCB group demonstrated significantly superior patient satisfaction compared to the GoLYTELY group (p < 0.001).
• No significant difference in colon cleanliness was observed between the two preparations.

Conclusions:

• A pill-based colonoscopy preparation of MCCB is an effective alternative for bowel cleansing.
• MCCB offers a potentially low-cost and well-tolerated option for patients hesitant about liquid preparations.
• This novel preparation may enhance adherence to colonoscopy screening guidelines.