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Renewal of Skin Epidermal Stem Cells01:12

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Related Experiment Video

Updated: Oct 5, 2025

Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
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Facial Skin Revitalization with Cohesive Polydensified Matrix-HA20G: Results from a Randomized Multicenter Clinical

Martina Kerscher1, Welf Prager2, Tanja C Fischer3

  • 1University of Hamburg, Hamburg, Germany.

Plastic and Reconstructive Surgery. Global Open
|January 24, 2022
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Cohesive polydensified matrix-hyaluronic acid + glycerol (CPM-HA20G) effectively improved skin hydration and revitalization in photodamaged facial skin. The treatment demonstrated safety and high subject satisfaction, particularly with multiple doses.

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Area of Science:

  • Dermatology and Aesthetic Medicine
  • Skin Rejuvenation Technologies
  • Biomaterials in Cosmetics

Background:

  • Growing interest in hyaluronic acid (HA) derivatives for enhancing skin quality.
  • Investigating novel HA formulations for dermatological applications.
  • Addressing early signs of photodamaged facial skin.

Purpose of the Study:

  • To evaluate the safety and effectiveness of cohesive polydensified matrix-hyaluronic acid + glycerol (CPM-HA20G; Belotero Revive).
  • To assess its efficacy in revitalizing early-onset photodamaged facial skin.
  • To compare single-dose versus multiple-dose treatment regimens.

Main Methods:

  • Randomized study of 159 subjects with early photodamaged skin.
  • Treatment with CPM-HA20G in multiple- or single-dose groups.
  • Assessed skin hydration, elasticity, firmness, roughness, and aesthetic improvement via validated scales and questionnaires.

Main Results:

  • Significant improvement in skin hydration for subjects with dry/very dry skin, sustained up to 9 months.
  • High subject and investigator satisfaction rates, with greater benefits in the multiple-dose group.
  • Transient, mild-to-moderate injection-site reactions were the only adverse events reported.

Conclusions:

  • CPM-HA20G is effective for improving skin hydration in subjects with dry or very dry skin.
  • Demonstrated safe and effective facial skin revitalization for early photodamaged skin.
  • Multiple-dose regimen showed higher satisfaction and efficacy in improving skin quality.